Expression of the Tn antigen on erythroid cells from a patient with Tn syndrome
نویسندگان
چکیده
منابع مشابه
Presence of the Tn antigen on hematopoietic progenitors from patients with the Tn syndrome.
The Tn syndrome is an acquired clonal disorder characterized by the exposure of a normally hidden determinant, the Tn antigen, on the surface of human erythrocytes, platelets, granulocytes, and lymphocytes. Two distinct populations, Tn positive (Tn+) and Tn negative (Tn-), of mature hemopoietic cells are present in Tn patients. To determine whether the Tn antigen is already expressed on erythro...
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Various T-lymphoid cells were labeled with [3H] glucosamine and then cell lysates were prepared from them. The Tn antigen was immunoprecipitated and analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by fluorography. The Tn antigen was found to be expressed on leukosialin, a major glycoprotein of T-lymphoid cells. The carbohydrate moieties of leukosialin were isolate...
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Sialosyl-Tn antigen and its immediate precursor, Tn antigen, are carbohydrate structures associated with the earliest steps of mucin O-linked glycosylation. Both antigens have been shown previously to be highly sensitive and specific markers of colorectal cancer. One hundred and three colorectal polyps (79 adenomatous; 24 hyperplastic) were examined for expression of Tn antigen using vicia vill...
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متن کاملImmunocytological analysis of the Tn associated antigen 83D4 in serous effusions from patients with cancer: comparison with Tn soluble glycoprotein.
AIMS To determine whether the monoclonal antibody (MoAb) 83D4, previously shown to be highly specific for carcinoma cells, can be used as an immunocytological marker to discriminate between benign and malignant cells in serous effusions; and to test for a correlation between expression of the antigen reacting with MoAb 83D4 on effusion cells and the amount of soluble 83D4 antigen in effusion fl...
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ژورنال
عنوان ژورنال: Japanese journal of human genetics
سال: 1992
ISSN: 0021-5074
DOI: 10.1007/bf01883318